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Anti-ITGB7 Antibody EPR1357
Also for ITGB7 (NM_000889)
|A synthetic peptide corresponding to residues in human Integrin beta-7 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; ICC: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens integrin, beta 7 (ITGB7), transcript variant 1|
|integrin beta 7 subunit; integrin, beta 7|
|The integrins are a large family of heterodimeric cell-surface glycoproteins that play key roles in the adherence of cells to other cells and to extracellular matrix proteins (1). They are all composed of 1 alpha subunit and 1 beta subunit (1). Integrin beta-7, a member of the integrin family, is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) by associating with integrin alpha-4 (2). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecule mucosal addressin cell adhesion molecule-1 (MADCAM1), which is normally expressed by the vascular endothelium of the gastrointestinal tract (2). Integrin alpha-4/beta-7 facilitates retention of effector and memory lymphocytes in the gut epithelial layer via interactions with E-cadherin (3). In addition, it is expressed in a variety of leukocyte lines (2).|
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Western blot - Integrin beta 7 antibody [EPR1357]; All lanes : Anti-Integrin beta 7 antibody [EPR1357] at 1/1000 dilution.Lane 1 : Human peripheral blood mononuclear lysate.Lane 2 : Human tonsil lysate.Lane 3 : THP-1 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 87 kDa.