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Home Antibody All anti-ITGB7 antibodies

Anti-ITGB7 Antibody EPR1357

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307663 Rabbit monoclonal antibody against Integrin beta-7(clone EPR1357) 100ul $325 In Stock
LC400325 ITGB7 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
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Also for ITGB7 (NM_000889)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Integrin beta-7 was used as an immunogen.
Clone NameEPR1357 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens integrin, beta 7 (ITGB7), transcript variant 1
Alternative Nameintegrin beta 7 subunit; integrin, beta 7
Database LinkNP_000880
Entrez Gene 3695 Human
FunctionThe integrins are a large family of heterodimeric cell-surface glycoproteins that play key roles in the adherence of cells to other cells and to extracellular matrix proteins (1). They are all composed of 1 alpha subunit and 1 beta subunit (1). Integrin beta-7, a member of the integrin family, is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) by associating with integrin alpha-4 (2). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecule mucosal addressin cell adhesion molecule-1 (MADCAM1), which is normally expressed by the vascular endothelium of the gastrointestinal tract (2). Integrin alpha-4/beta-7 facilitates retention of effector and memory lymphocytes in the gut epithelial layer via interactions with E-cadherin (3). In addition, it is expressed in a variety of leukocyte lines (2).
Related PathwayTransmembraneDruggable Genome Focal adhesionECM-receptor interactionCell adhesion molecules (CAMs)Regulation of actin cytoskeletonHypertrophic cardiomyopathy (HCM)Arrhythmogenic right ventricular cardiomyopathy (ARVC)More Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Integrin beta 7 antibody [EPR1357]; All lanes : Anti-Integrin beta 7 antibody [EPR1357] at 1/1000 dilution.Lane 1 : Human peripheral blood mononuclear lysate.Lane 2 : Human tonsil lysate.Lane 3 : THP-1 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 87 kDa.
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