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Home Antibody All anti-ITGB7 antibodies

Anti-ITGB7 Antibody EPR1357

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307663
  • Rabbit monoclonal antibody against Integrin beta-7(clone EPR1357)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400325) , 20ug
100ul 325 In Stock
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WB(1)
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Also for ITGB7 (NM_000889)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Integrin beta-7 was used as an immunogen.
Clone NameEPR1357 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens integrin, beta 7 (ITGB7), transcript variant 1
Alternative Nameintegrin beta 7 subunit; integrin, beta 7
Database LinkNP_000880
FunctionThe integrins are a large family of heterodimeric cell-surface glycoproteins that play key roles in the adherence of cells to other cells and to extracellular matrix proteins (1). They are all composed of 1 alpha subunit and 1 beta subunit (1). Integrin beta-7, a member of the integrin family, is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) by associating with integrin alpha-4 (2). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecule mucosal addressin cell adhesion molecule-1 (MADCAM1), which is normally expressed by the vascular endothelium of the gastrointestinal tract (2). Integrin alpha-4/beta-7 facilitates retention of effector and memory lymphocytes in the gut epithelial layer via interactions with E-cadherin (3). In addition, it is expressed in a variety of leukocyte lines (2).
Related Pathway
Focal Adhesion

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WB Image
Western blot - Integrin beta 7 antibody [EPR1357]; All lanes : Anti-Integrin beta 7 antibody [EPR1357] at 1/1000 dilution.Lane 1 : Human peripheral blood mononuclear lysate.Lane 2 : Human tonsil lysate.Lane 3 : THP-1 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 87 kDa.

 

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