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Home Antibody All anti-ITGB3 antibodies

Anti-ITGB3 PHOSPHO Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA323714
  • Anti-ITGB3 (Phospho-Tyr785) Rabbit Polyclonal Antibody
100ul $325 2-3 Weeks
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WB(1)
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Also for ITGB3 (NM_000212)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPeptide sequence around phosphorylation site of tyrosine 785 (I-T-Y(p)-R-G) derived from Human Integrin ß3.
Clone Name IsotypeIgG
Species ReactivityHuman; Mouse Concentration1mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:500-1000
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3)
Alternative NameBDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT
Database LinkNP_000203
FunctionIntegrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Related Pathway
Focal Adhesion
Hematopoietic cell lineage
Hemostasis

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WB Image
Predicted band size: 87 kDa . Positive control: HUVEC cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: Treated with the peptide Lane2: HUVEC cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

 

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