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Anti-ITGB3 Antibody EPR2342
Also for ITGB3 (NM_000212)
|A synthetic peptide corresponding to residues in human Integrin beta-3 (CD61 antigen) was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3)|
|BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT|
|Integrin beta-3 (CD61 antigen, GP IIIa) is a member of the integrin family of integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins (1). Integrin beta-3 forms a Ca2+-dependent heterodimer complex with the GP IIb chain in platelets (2). The cytoplasmic domain of Integrin beta-3 has be suggested to have a key role in cell adhesion (3). Following activation integrin beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surfaces (4). |
Hematopoietic cell lineage
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Western blot - Anti-Integrin beta 3 antibody [EPR2342]; All lanes : Anti-Integrin beta 3 antibody [EPR2342] at 1/1000 dilution.Lane 1 : TPA treated THP1 cell lysate.Lane 2 : HUVEC cell lysate.Lane 3 : Human spleen lysate.Lane 4 : Human plasma lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 87 kDa.Observed band size : 110 kDa .