Homo sapiens integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A
Synonyms:
CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA; VLAB
Immunogen
A phospho specific peptide corresponding to residues surrounding Tyrosine 783 of human Integrin ?-1 (CD29). This antibody detect Integrin ?-1 phosphorylated at Tyrosine 783.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Integrin beta-1 (ITGB1, CD29, VLA-beta) is the beta subunit found in the integrin families, forming a heterodimer integrin receptor through non-covalent bonding with various integrin alpha subunits. Integrin heterodimer containing Integrin beta-1 binds to various cell surface and extracellular proteins (CD49a-f, CD51) to mediate cell to cell and cell to matrix adhesion (1). Integrin beta-1 plays a critical role in the cell adhesion and recognition in embryogenesis, hemostasis, immune response, tissue repair, metastatic diffusion of tumor cells and development (2, 3, 4). Observations argue that tyrosines 783 and 795 within the cytoplasmic tail of integrin subunit beta1A are critical mediators of FAK activation and cell spreading in GD25 cells (5).
Related Pathway
Focal Adhesion
Hemostasis
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Western blot analysis on U937 cell lysates using anti-Phospho-Integrin β-1 (CD29) (pY783), 1:100,000 dilution. Cells were either (A) untreated (B) treated with pervanadate.
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