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Home Antibody All anti-ITGAM antibodies

Anti-ITGAM Antibody EPR1344

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307682
  • Rabbit monoclonal antibody against CD11b/ITAM (clone EPR1344 )
  • FREE positive control: HEK293T cell transient overexpression lysate (LC424601) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(2)
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Also for ITGAM (NM_000632)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CD11b was used as an immunogen.
Clone NameEPR1344 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:5000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; FC: 1:100
BufferDoes not react with Rat. Is unsuitable for IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens integrin, alpha M (complement component 3 receptor 3 subunit) (ITGAM), transcript variant 2
Alternative NameCD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6
Database LinkNP_000623
FunctionIntegrin alpha-M (ITAM, ITGAM, CD11b, MAC-1 alpha subunit, CR3 alpha chain) belongs to integrin alpha chain family and it is predominately presented in human myeloid cells, NK1 cells, monocytes, and granulocytes. The alpha subunit of ITAM/beta-2 complex (CD11b/CD18, Mac-1), is complex is a receptor for fibrinogen (binding to P1 and P1 peptides of gamma chain), factor X, and ICAM1. ITAM/beta-2 is implicated in adhesive interactions of monocytes, macrophages, and granulocytes. It is also linked to mediation of complement-coated particle uptake (2).
Related Pathway
Focal Adhesion
Hematopoietic cell lineage
Hemostasis

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-CD11b antibody [EPR1344]; All lanes : Anti-CD11b [EPR1344] antibody at 1/1000 dilution.Lane 1 : THP1 cell lysate treated with TPA.Lane 2 : TF1 cell lysate .Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 127 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11b antibody [EPR1344]; Immunohistochemical analysis of CD11b in paraffin embedded Human tonsil tissue, using TA307682 at a dilution of 1/100.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11b antibody [EPR1344]; Immunohistochemical analysis of CD11b in paraffin embedded Human spleen tissue, using TA307682 at a dilution of 1/100.

 

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