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Home Antibody All anti-ITGA4 antibodies

Anti-ITGA4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306654
  • Rabbit Polyclonal Integrin alpha 4 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400316) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for ITGA4 (NM_000885)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenIntegrin alpha 4 antibody was raised against a 16 amino acid peptide from near the center of human Integrin alpha 4.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, IF
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (ITGA4)
Alternative NameCD49D; IA4
Database LinkNP_000876
FunctionThe integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha 4 chain associates with either beta 1 or beta 7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha 4 beta 1 and alpha 4 beta 7 is located on the alpha 4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha 4 beta 7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha 4 beta 1, the gut mucosal homing receptor for peripheral T cells. Despite its predicted molecular weight, Integrin alpha 4 will often run at higher molecular weight in SDS-PAGE. At least two isoforms are known to exist.
Related Pathway
Focal Adhesion
Hematopoietic cell lineage
Hemostasis

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WB Image
Western blot analysis of Integrin alpha 4 using (A) 25 and (B) 100 ng of recombinant Integrin alpha 4 with Integrin alpha 4 antibody at 1 ug/mL.
IF Image
Immunofluorescence of Integrin alpha 4 in Jurkat cells with Integrin alpha 4 antibody at 2 ug/mL.

 

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