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Home Antibody All anti-ITGA4 antibodies

Anti-ITGA4 PHOSPHO Antibody EPR2343

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301326
  • Rabbit Monoclonal Antibody against ITGA4 (Clone EPR2343) (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
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Also for ITGA4 (NM_000885)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues on human Integrin alpha 4 was used as an immunogen. The antibody only detects Integrin alpha4 phosphorylated on Serine 1027. The antibody detects the mature chain (180 kDa), the precursor (140 kDa) and the cleaved C terminal (70 kDa).
Clone NameEPR2343 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500 - 1:2000
Predicted MW Explanation 150 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (ITGA4)
Alternative NameCD49D; IA4
Database LinkNP_000876
Entrez Gene 3676 Human
Entrez Gene 16401 Mouse
Entrez Gene 311144 Rat
FunctionIntegrin alpha 4 is a cell surface heterodimer (VLA4, CD49d/CD29) which belongs to the integrin family and is involved in cell-extracellular matrix interactions, as well as in intercellular adhesion. Unlike other integrin alpha subunits, the alpha subunit of Integrin alpha 4 can appear as a 150-kDa polypeptide (alpha 150), or cleaved into two non-covalently associated polypeptides (alpha 70-80). The relative proportion of each form is highly variable among different cells and is dependent on the state of cellular activation (1). Integrin alpha 4 regulates cellular functions, differently from other integrins, through its cytoplasmic tail, making it indispensable for embryogenesis, haematopoiesis and immune responses (2). Integrin alpha 4, initially discovered on lymphoid cells, is actually known to be highly expressed on T cells, B cells, monocytes, and derived cell lines (3). It has a key function in the adhesion interaction between stem/progenitor cells and the stromal microenvironmental cells and their matrix within the bone marrow (4).
Related PathwayES Cell Differentiation/IPSTransmembraneDruggable Genome Focal adhesionECM-receptor interactionCell adhesion molecules (CAMs)Hematopoietic cell lineageLeukocyte transendothelial migrationRegulation of actin cytoskeletonMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Integrin alpha 4 (phospho S1027) antibody [EPR2343]; All lanes : Anti-Integrin alpha 4 (phospho S1027) antibody [EPR2343] at 1/2000 dilution.Lane 1 : THP1 cell lysates, untreated .Lane 2 : THP1 cell lysates, with Lambda Phosphatase.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 150 kDa.Observed band size : 70,140,180 kDa .

 

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