CD41 is also known as integrin alpha 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD41 / Integrin alpha 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling.
Hematopoietic cell lineage
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