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Anti-ITGA2B Antibody EPR4330
Also for ITGA2B (NM_000419)
|A synthetic peptide corresponding to residues in the extracellular domain in human CD41 / Integrin alpha 2b was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for IP.|
Preservative: 0.01% Sodium azide
Constituents: 59% Tris glycine, 40% Glycerol, 0.88% Sodium chloride, 0.05% BSA
|Is unsuitable for IP.
|Homo sapiens integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (ITGA2B)|
|BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; PPP1R93|
|CD41 is also known as integrin alpha 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD41 / Integrin alpha 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling. |
Hematopoietic cell lineage
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Western blot - Anti-CD41/Integrin alpha 2b antibody [EPR4330]; All lanes : Anti-CD41/Integrin alpha 2b antibody [EPR4330] at 1/1000 dilution.Lane 1 : Human platelet lysate.Lane 2 : Human fetal liver lysate.Lane 3 : Human placenta lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti rabbit at 1/2000 dilution.Predicted band size : 113 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD41/Integrin alpha 2b antibody [EPR4330]; Immunohistochemical analysis of paraffin-embedded Human spleen tissue labelling CD41/Integrin alpha 2b with TA310956 at 1/100 dilution.