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Anti-ITCH Antibody EPR4937
Also for ITCH (NM_001257137)
|A synthetic peptide corresponding to residues in human ITCH was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:10000 - 1:50000; IHC-P: 1:500 - 1:1000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens itchy E3 ubiquitin protein ligase (ITCH), transcript variant 1|
|AIF4; AIP4; dJ468O1.1; NAPP1|
|ITCH, or Atrophin-1, contains a polyglutamine repeat, the expansion of which is responsible for dentatorubral and pallidoluysian atrophy. It is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. ITCH contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2, and it may participate in the regulation of immune responses by modifying Notch-mediated signaling. ITCH is highly similar to the mouse ITCH protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.|
Delta-Notch Signaling Pathway
EGFR1 Signaling Pathway
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Western blot - ITCH/AIP4 antibody [epr4937]; All lanes : Anti-ITCH/AIP4 antibody [EPR4937] at 1/10000 dilution.Lane 1 : K562 cell lysate.Lane 2 : HL60 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 103 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ITCH/AIP4 antibody [epr4937]; Immunohistochemical analysis of ITCH/AIP4 expression in paraffin-embedded Human breast tissue using ab109018 at 1/500 dilution.