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Anti-ITCH Antibody epr4937

WB(1)

IHC(1)

Gene Name Homo sapiens itchy E3 ubiquitin protein ligase (ITCH), transcript variant 1 Synonyms: AIF4; AIP4; dJ468O1.1; NAPP1 Immunogen A synthetic peptide corresponding to residues in human ITCH was used as an immunogen. Buffer Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt. Clone Name epr4937 Isotype Species Reactivity Human, Mouse, Rat Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB, IHC Suggested Dilutions WB: 1:1,000 - 10,000; Background ITCH, or Atrophin-1, contains a polyglutamine repeat, the expansion of which is responsible for dentatorubral and pallidoluysian atrophy. It is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. ITCH contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2, and it may participate in the regulation of immune responses by modifying Notch-mediated signaling. ITCH is highly similar to the mouse ITCH protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. Related Pathway Delta-Notch Signaling Pathway EGFR1 Signaling Pathway

Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • ITCH - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • ITCH - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Itch - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • ITCH - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Itch - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones Related cDNA Clones

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)