Home Antibody All anti-ITCH antibodies
Also for ITCH (NM_031483)
|Peptide with sequence C-EIKSHDLKPNGGN, from the internal region of the protein sequence according to NP_113671.3.|
|Test: Human. Expected from seq similarity: Human, Mouse, Rat, Dog
||ELISA: 1:32,000. WB: 0.03-0.1µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens itchy E3 ubiquitin protein ligase (ITCH), transcript variant 2|
|ADMFD; AIF4; AIP4; dJ468O1.1; NAPP1|
Entrez Gene 83737 Human
Entrez Gene 16396 Mouse
Entrez Gene 311567 Rat
Entrez Gene 477199 Dog
|Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. [provided by RefSeq]. |
|Transcription FactorsDruggable Genome Ubiquitin mediated proteolysisEndocytosis|
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TA302519 (0.03µg/ml) staining of Human Brain (Frontal Cortex) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.