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Home Antibody All anti-IRS2 antibodies

Anti-IRS2 Antibody EPR1650(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307343
  • Rabbit monoclonal antibody against IRS-2 antibody(clone EPR1650(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418459) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human IRS-2 was used as an immunogen.
Clone NameEPR1650(2) IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens insulin receptor substrate 2 (IRS2)
Alternative NameIRS-2
Database LinkNP_003740
Entrez Gene 8660 Human
FunctionInsulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). Sequences of IRS-2 and IRS-1 reveal a highly conserved amino terminus containing a pleckstrin-homology domain and a phosphotyrosine-binding domain, and a poorly conserved carboxy terminus containing several tyrosine phosphorylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1-/- mice, and may be essential for signaling by several receptor systems such as insulin and cytokine (1).
Related PathwayDruggable Genome Neurotrophin signaling pathwayInsulin signaling pathwayAdipocytokine signaling pathwayType II diabetes mellitus

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-IRS2 antibody [EPR1650(2)]; All lanes : Anti-IRS2 antibody [EPR1650(2)] at 1/1000 dilution.Lane 1 : 293T cell lysate.Lane 2 : 293T+insulin cell lysate.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 137 kDa.

 

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