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Home Antibody All anti-IRS1 antibodies

Anti-IRS1 PHOSPHO Antibody EPR259(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307870
  • Rabbit monoclonal antibody against IRS-1 Phospho (pY632)(clone EPR259(2)) (Phospho-Specific)
100ul $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Tyrosine 632 of human IRS-1 was used as an immunogen. This antibody only detects IRS-1 phosphorylated at Tyrosine 632.
Clone NameEPR259(2) IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens insulin receptor substrate 1 (IRS1)
Alternative NameHIRS-1
Database LinkNP_005535
FunctionInsulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1, 2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2, 3). IRS-1 functions as one of the key regulators of IR and the insulin-like growth factor-1 receptor. Disruption of IRS-1 causes growth retardation and insulin resistance associated with hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation (4, 5).
Related Pathway
Adipogenesis

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WB Image
Western blot - IRS1 (phospho Y632) antibody [EPR259(2)]; All lanes : Anti-IRS1 (phospho Y632) antibody [EPR259(2)] at 1/1000 dilution.Lane 1 : 293T cell lysate, untreated.Lane 2 : 293T cell lysate treated with Alkaline Phosphatase.Lysates/proteins at 10 µg per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 132 kDa.

 

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