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Home Antibody All anti-IRGM antibodies

Anti-IRGM Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306553 Rabbit Polyclonal IRGM Antibody 100ug $325 3 Weeks
LC429013 IRGM HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenIRGM antibody was raised against a 14 amino acid peptide near the center of the human IRGM.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens immunity-related GTPase family, M (IRGM)
Alternative NameIFI1; IRGM1; LRG-47; LRG47
Database LinkNP_001139277
Entrez Gene 345611 Human
Entrez Gene 303090 Rat
FunctionAutophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn’s disease. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of IRGM in human brain lysate with IRGM antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of IRGM in human brain with IRGM antibody at 5 ug/ml.


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