Home Antibody All anti-IRGC antibodies
Also for IRGC (NM_019612)
|IRGC antibody was raised against a 13 amino acid peptide near the amino terminus of human IRGC.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml, ICC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens immunity-related GTPase family, cinema (IRGC)|
|CINEMA; IFGGE; Iigp5; IRGC1; R30953_1|
Entrez Gene 56269 Human
Entrez Gene 308428 Rat
|Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans. Two isoforms of IRGC are known to exist; this antibody will only recognize the IRGCa isoform.|
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Western blot analysis of IRGC in A20 cell lysate with IRGC antibody at (A) 1 and (B) 2 ug/mL.
Immunofluorescence of IRGCa in A20 cells with IRGCa antibody at 20 ug/mL.