Home Antibody All anti-IRF7 antibodies
Also for IRF7 (NM_001572)
|IRF7 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy-terminus of human IRF7 .|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens interferon regulatory factor 7 (IRF7), transcript variant a|
|IRF-7H; IRF7A; IRF7B; IRF7C; IRF7H|
Entrez Gene 3665 Human
Entrez Gene 54123 Mouse
Entrez Gene 293624 Rat
|Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.|
|Transcription Factors Toll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway|
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Western blot analysis of IRF7 in 293 whole cell lysate with IRF7 antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry of ?IRF7 in mouse spleen tissue with IRF7 antibody at 5 ug/ml.