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Home Antibody All anti-IRF3 antibodies

Anti-IRF3 TRUEMAB Antibody Clone OTI4D4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA500476 IRF3 mouse monoclonal antibody, clone OTI4D4 (formerly 4D4) 100ul $379 In Stock
LC400600 IRF3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF500476 Carrier-free (BSA/glycerol-free) IRF3 mouse monoclonal antibody, clone OTI4D4 (formerly 4D4) 100ug $450 3-4 weeks
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WB(2)
IHC(1)
IF(1)
FC(1)

OriGene Data

ImmunogenFull length human recombinant protein of human IRF3 (NP_001562) produced in HEK293T cell.
Clone NameClone OTI4D4 IsotypeIgG2a
Species ReactivityHuman Concentration1.2 mg/ml
Guaranteed Application *WB, IHC, IF, FC Suggested DilutionsWB 1:1000~2000, IHC 1:50, IF 1:100, FLOW 1:100,
Predicted MW Explanation 47 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens interferon regulatory factor 3 (IRF3), transcript variant 1
Alternative NameMGC94729; interferon regulatory factor 3
Database LinkNP_001562
Entrez Gene 3661 Human
FunctionIRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants have been described. [provided by RefSeq].
Related PathwayTranscription FactorsDruggable Genome Toll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IRF3 (RC209951, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IRF3.
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Western blot analysis of extracts (35ug) from 9 different cell lines by usin g anti-IRF3 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
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Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-IRF3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500476)
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Anti-IRF3 mouse monoclonal antibody (TA500476) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IRF3(RC209951).
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HEK293T cells transfected with either RC209951 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-IRF3 antibody(TA500476), and then analyzed by flow cytometry.
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