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Home Antibody All anti-IRAK1 antibodies

Anti-IRAK1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319668 Mouse IRAK Monoclonal Antibody 100ug $325 In Stock
LC422494 IRAK1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenRecombinant protein corresponding to amino acids 618 - 712 of human IRAK.
Clone Name IsotypeIgG1
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/mL, ICC: 5 ug/mL
BufferIRAK Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Purification IRAK Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Reference Data

Target NameHomo sapiens interleukin-1 receptor-associated kinase 1 (IRAK1), transcript variant 2
Alternative NameIRAK; pelle
Database LinkNP_001020413
Entrez Gene 3654 Human
Entrez Gene 16179 Mouse
FunctionIRAK Monoclonal Antibody: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
Related PathwayProtein KinaseTranscription FactorsDruggable Genome ApoptosisToll-like receptor signaling pathwayNeurotrophin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of IRAK in mouse liver lysate with IRAK antibody at (A) 1 and (B) 2 ug/mL.

IHC Image
Immunohistochemistry of IRAK in rat liver tissue with IRAK antibody at 5 ug/mL.


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