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Also for IPO7 (NM_006391)
|Synthetic peptide corresponding to a region within amino acids 976 and 1038 of Importin 7 (Uniprot ID#O95373)|
|Human (Predicted: Mouse, Rat, Zebrafish, Xenopus laevis, Xenopus Tropicalis, Bovine)
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (100%), Rat (100%), Zebrafish (92%), Xenopus laevis (85%), Xenopus Tropicalis (92%), Bovine (100%)
|Homo sapiens importin 7 (IPO7)|
Entrez Gene 10527 Human
Entrez Gene 233726 Mouse
Entrez Gene 308939 Rat
|The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq]|
|Druggable Genome |
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Sample (30 ug of whole cell lysate). A: JurKat. 7.5% SDS PAGE. TA308330 diluted at 1:1000.
Immunohistochemical analysis of paraffin-embedded Huh7 xenograft, using Importin 7(TA308330) antibody at 1:100 dilution.
Importin 7 antibody [C3], C-term detects IPO7 protein at cytoplasm by immunofluorescent analysis. Sample: A431 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: IPO7 protein stained by Importin 7 antibody [C3], C-term (TA308330) diluted at