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Anti-INSR PHOSPHO Antibody EP351(2)Y


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against INSR/IGF-R (pY1185) Phospho (EP351(2)Y ) (phospho-specific)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA phospho synthetic peptide corresponding to residues surrounding Tyrosine 1185 of human INSR was used as an immunogen. This antibody detects INSR phosphorylated at Tyrosine 1185.
Clone NameEP351(2)Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:2000; IP: 1:20; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens insulin receptor (INSR), transcript variant 1
Alternative NameCD220; HHF5
Database LinkNP_000199
Entrez Gene 3643 Human
FunctionAfter removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Related PathwayProtein KinaseTransmembraneDruggable Genome Adherens junctionInsulin signaling pathwayType II diabetes mellitus

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Insulin Receptor (phospho Y1185) antibody [EP351(2)Y]; All lanes : Anti-Insulin Receptor (phospho Y1185) antibody [EP351(2)Y] at 1/500 dilution.Lane 1 : HepG2 cell lysate; untreated.Lane 2 : HepG2 cell lysate; Insulin treated.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP conjugated, at 1/2000 dilution.Predicted band size : 156 kDa.Observed band size : 95 kDa .


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