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Anti-INPP5D PHOSPHO Antibody EPR425
Also for INPP5D (NM_005541)
|A synthetic peptide corresponding to residues surrounding Tyrosine 1020 of human SHIP was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:20; ICC: 1:250 - 1:500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt or IHC-P.
|Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 2|
|hp51CN; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145|
Entrez Gene 3635 Human
|SH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2). Phosphorylation on tyrosine 917 and tyrosine 1020 sites in SHIP have been shown to control migration by binding to DOK1, a regulating protein linked to the regulation of migration (3). |
|Druggable Genome Phosphatidylinositol signaling systemB cell receptor signaling pathwayFc epsilon RI signaling pathwayFc gamma R-mediated phagocytosisInsulin signaling pathway|
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Western blot - SHIP (phospho Y1022) antibody [EPR425]; All lanes : Anti-SHIP (phospho Y1020) antibody [EPR425] at 1/1000 dilution.Lane 1 : Untreated Raji cell lysates .Lane 2 : Raji cell lysates treated with Pervanadate.Lysates/proteins at 10 ug per lane.Secondary.HRP/AP polymerized antibody.Predicted band size : 133 kDa.Observed band size : 145 kDa .