Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens inositol polyphosphate-4-phosphatase, type II, 105kDa (INPP4B), transcript variant 2
Synonyms:
MGC132014
Immunogen
A synthetic peptide corresponding to residues at the N-terminus of human INPP4B type II was used as immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Inositol polyphosphate 4-phosphatase (INPP4B) is an Mg2+ independent enzyme involved in phosphatidylinositol signaling pathways. INPP4B type II catalyses the hydrolysis of the 4-position phosphate from phosphatidylinositol 3,4-bisphosphate. 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. This process rapidly generates two second messengers phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate in response to extracellular signal (1). INPP4B and its secondary messengers have been linked to cell growth, differentiation, apoptosis, protein trafficking, and cell motility (2). It is suggested that INPP4B type II might be subject to alternative splicing, similar to type I enzyme. However, additional factors and/or processing maybe required for alternative isozymes to be active (3).
Related Pathway
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
