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Also for INHBA (NM_002192)
|Synthetic peptide corresponding to a region within amino acids 362 and 426 of Inhibin beta A|
|Human (Predicted: Mouse, Rat, Cat, Pig, Chicken, Sheep, Bovine)
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (100%), Rat (100%), Cat (100%), Pig (100%), Chicken (100%), Sheep (100%), Bovine (100%)
|Homo sapiens inhibin, beta A (INHBA)|
Entrez Gene 3624 Human
Entrez Gene 16323 Mouse
Entrez Gene 29200 Rat
|The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq]|
|Secreted ProteinDruggable Genome Cytokine-cytokine receptor interactionTGF-beta signaling pathway|
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Sample(30 ug whole cell lysate). A:H1299. B:HeLa S3. C:Hep G2 . 10% SDS PAGE. TA308909 diluted at 1:1000
Immunohistochemical analysis of paraffin-embedded CLEAR CELL OVCA xenograft, using Inhibin beta A(TA308909) antibody at 1:500 dilution.
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Inhibin beta-A (TA308909) antibody at 1:200 dilution.