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Anti-INCENP Antibody EPR3542(2)


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against INCENP(clone EPR3542(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC420743) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human INCENP was used as an immunogen.
Clone NameEPR3542(2) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:100 - 1:250; ICC/IF: Use at an assay dependent concentration
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens inner centromere protein antigens 135/155kDa (INCENP), transcript variant 1
Alternative NameFLJ31633; MGC111393
Database LinkNP_001035784
Entrez Gene 3619 Human
FunctionINCENP, or inner centromere protein, is a chromosomal passenger protein that is a component of the chromosomal passenger complex (CPC), which acts as a key regulator of mitosis (1, 2). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation, and it is required for chromatin-induced microtubule stabilization and spindle assembly (2). INCENP, Survivin, and Borealin are three components of the CPC complex that regulate the activity and localization of its enzymatic component, the kinase Aurora B (3). INCENP localizes on chromosome arms and inner centromeres from prophase through metaphase, subsequently transferring to the spindle midzone and midbody from anaphase through cytokinesis (2). During telophase, INCENP is located within the midbody in the intercellular bridge, where it is discarded after cytokinesis (1).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-INCENP antibody [EPR3542(2)]; All lanes : Anti-INCENP antibody [EPR3542(2)] at 1/1000 dilution.Lane 1 : Molt4 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : PC3 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 105 kDa.Observed band size : 140 kDa .
Immunocytochemistry/ Immunofluorescence - Anti-INCENP antibody [EPR3542(2)]; Immunofluorescent staining of HeLa cells labelling INCENP with TA307618 at 1/100.


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