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Home Antibody All anti-IMPDH2 antibodies

Anti-IMPDH2 Antibody EPR8365(B)

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SKU Description Amount Price Availability*  
TA310629
  • Rabbit Monoclonal antibody against IMPDH2
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424469) , 20ug Explanation
100ul $325 3-7 Days
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WB(1)
IHC(1)
IF(1)
Assay(1)
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Also for IMPDH2 (NM_000884)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus in human IMPDH2 was used as an immunogen.
Clone NameEPR8365(B) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; FC: 1:10 - 1:100; ICC/IF: 1:250 - 1:500
Predicted MW Explanation 56 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 2 (IMPDH2)
Alternative NameIMPD2; IMPDH-II
Database LinkNP_000875
Entrez Gene 3615 Human
Entrez Gene 23918 Mouse
Entrez Gene 301005 Rat
FunctionIMPDH2 is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. It catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation (1).
Related PathwayDruggable Genome Purine metabolismDrug metabolism - other enzymesMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-IMPDH2 antibody [EPR8365(B)]; All lanes : Anti-IMPDH2 antibody [EPR8365(B)] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : A549 cell lysate.Lane 3 : MCF7 cell lysate.Lane 4 : HeLa cell lysate.Lane 5 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti-Rabbit IgG at 1/2000 dilution.Predicted band size : 56 kDa.Observed band size : 56 kDa.
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Other-Anti-IMPDH2 antibody [EPR8365(B)](TA310629); Equilibrium disassociation constant (KD)..
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPDH2 antibody [EPR8365(B)]; TA310629, at 1/250 dilution, staining IMPDH2 in paraffin-embedded Human kidney tissue by Immunohistochemistry.
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Immunocytochemistry/ Immunofluorescence - Anti-IMPDH2 antibody [EPR8365(B)]; TA310629, at 1/250 dilution, staining IMPDH2 in MCF7 cells by Immunofluorescence.
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