Home Antibody All anti-IL6R antibodies
Anti-IL6R TRUEMAB Antibody Clone 2F4
TrueMAB Antibodies - Made against Authentic Protein Antigens
Also for IL6R (NM_000565)
|Full length human recombinant protein of human IL6R(NP_000556) produced in HEK293T cell.|
|WB, IHC, IF
|| WB 1:4000, IHC 1:150, IF 1:100,
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens interleukin 6 receptor (IL6R), transcript variant 1|
|CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ|
Entrez Gene 3570 Human
|This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]. |
|ES Cell Differentiation/IPSTransmembraneDruggable Genome Cytokine-cytokine receptor interactionJak-STAT signaling pathwayHematopoietic cell lineage|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL6R (RC221874, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL6R.
Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-IL6R mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506859)
Anti-IL6R mouse monoclonal antibody (TA506859) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IL6R(RC221874).