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Anti-IL6R TRUEMAB Antibody Clone OTI2F4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA506859 IL6R mouse monoclonal antibody, clone OTI2F4 (formerly 2F4) 100ul 325
In Stock
LC400192 IL6R HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF506859 Carrier-free (BSA/glycerol-free) IL6R mouse monoclonal antibody, clone OTI2F4 (formerly 2F4) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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OriGene Data

ImmunogenFull length human recombinant protein of human IL6R(NP_000556) produced in HEK293T cell.
Clone NameClone OTI2F4 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC, IF Suggested Dilutions WB 1:4000, IHC 1:150, IF 1:100,
Predicted MW Explanation 49.8 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens interleukin 6 receptor (IL6R), transcript variant 1
Alternative NameCD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ
Database LinkNP_000556
Entrez Gene 3570 Human
FunctionThis gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011].
Related PathwayES Cell Differentiation/IPSTransmembraneDruggable Genome Cytokine-cytokine receptor interactionJak-STAT signaling pathwayHematopoietic cell lineage

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL6R (RC221874, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL6R.

IHC Image
Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-IL6R mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506859)

IF Image
Anti-IL6R mouse monoclonal antibody (TA506859) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IL6R(RC221874).


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