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Home Antibody All anti-IL33 antibodies

Anti-IL33 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306447
  • Rabbit Polyclonal IL-33 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC409498) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for IL33 (NM_033439)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenIL-33 antibody was raised against a 19 amino acid peptide from near the amino terminus of human IL-33.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 - 2 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens interleukin 33 (IL33), transcript variant 1
Alternative NameC9orf26; DVS27; IL1F11; NF-HEV; NFEHEV
Database LinkNP_254274
Entrez Gene 90865 Human
FunctionInterleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1a/b, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-kappaB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE.
Related PathwaySecreted Protein Cytosolic DNA-sensing pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of IL-33 in human lymph node tissue lysate with IL-33 antibody at (A) 1 and (B) 2 ug/mL.
IF Image
Immunofluorescence of IL-33 in human lymph node tissue with IL-33 antibody at 20 ug/mL.

 

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