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Home Antibody All anti-IL27 antibodies

Anti-IL27 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306316
  • Rabbit Polyclonal IL-27 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403437) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenIL-27 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-27.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 2 - 4 ug/ml, ICC: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens interleukin 27 (IL27)
Alternative NameIL-27; IL-27A; IL27A; IL27p28; IL30; p28
Database LinkNP_663634
FunctionLike interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.
Related Pathway

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WB Image
Western blot analysis of IL-27 in EL4 lysate with IL-27 antibody at (A) 2 and (B) 4 ug/mL.
IF Image
Immunocytochemistry of IL-27 in EL4 with IL-27 antibody at 10 ug/mL.

 

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