Home Antibody All anti-IL23A antibodies
Also for IL23A (NM_016584)
|IL-23 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human IL-23.|
||ELISA, WB: 1 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens interleukin 23, alpha subunit p19 (IL23A)|
|IL-23; IL-23A; IL23P19; P19; SGRF|
Entrez Gene 51561 Human
Entrez Gene 83430 Mouse
|Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-alpha from activated T cells, and can stimulate macrophages to produce TNF-alpha and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.|
|Secreted ProteinDruggable Genome Cytokine-cytokine receptor interactionJak-STAT signaling pathway|
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Western blot analysis of IL-23 in Raji lysate with IL-23 antibody at 1 ug/mL in the (A) absence and (B) presence of blocking peptide.
Immunocytochemistry of IL-23 in Raji cells with IL-23 antibody at 10 ug/mL.