Home Antibody All anti-IL16 antibodies
Also for IL16 (NM_001172128)
|IL-16 antibody was raised against a 14 amino acid peptide near the amino terminus of human IL-16.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens interleukin 16 (IL16), transcript variant 3|
|LCF; NIL16; prIL-16; PRIL16|
|IL-16 was initially identified as a chemotactic cytokine, but is now known to possess a wide range of activities. Later studies have more fully characterized IL-16 as an immunomodulatory cytokine that contributes to the regulatory process of CD4+ T cell recruitment and activation at sites of inflammation in association with asthma and several autoimmune diseases. The precursor of IL-16 (pro-IL-16) is thought to be cleaved towards the C-terminal region by Caspase-3, releasing a 20 kDa active form that binds to and signals through CD4. Besides acting as a chemotactic cytokine, IL-16 is thought to also be involved in the regulation of T cell proliferation and multiple infectious, immune-mediated, and autoimmune inflammatory disorders including irritable bowel syndrome, systemic lupus erythematosus, and neurodegenerative disorders. At least two isoforms of IL-16 are known to exist; the longer isoform (also known as NIL-16) is detected only in neurons of the cerebellum and hippocampus. This antibody will only detect the NIL-16 isoform.|
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Western blot analysis of IL-16 in rat brain tissue lysate with IL-16 antibody at (A) 1 ug/ml and (B) 2 ug/mL.
Immunohistochemistry of IL-16 in mouse brain tissue with IL-16 antibody at 2.5 ug/mL.