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Home Antibody All anti-IKBKB antibodies

Anti-IKBKB Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308825
  • Rabbit polyclonal antibody to IKK beta (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC419865) , 20ug
100ul $325 3-7 Days
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WB(1)
IF(1)
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Also for IKBKB (NM_001556)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 493 and 709 of IKK beta
Clone Name IsotypeIgG
Species ReactivityHuman Concentration0.41mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB:1:500-1:3000; IF:1:100-1:200;
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB), transcript variant 1
Alternative NameIKK-beta; IKK2; IKKB; IMD15; NFKBIKB
Database LinkNP_001547
FunctionNFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
Related Pathway
Apoptosis
MAPK signaling pathway
Toll-like receptor signaling pathway

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WB Image
A: A431 (anti-IKBKB antibody diluted at 1:1000)
IF Image
Immunofluorescence analysis of paraformaldehyde-fixed A431, using IKK beta(anti-IKBKB antibody) antibody at 1:200 dilution.

 

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