Home Antibody All anti-IKBKB antibodies
Also for IKBKB (NM_001556)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 493 and 709 of IKK beta|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB), transcript variant 1|
|IKK-beta; IKK2; IKKB; NFKBIKB|
|NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]|
MAPK signaling pathway
Toll-like receptor signaling pathway
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A: A431 (anti-IKBKB antibody diluted at 1:1000)
Immunofluorescence analysis of paraformaldehyde-fixed A431, using IKK beta(anti-IKBKB antibody) antibody at 1:200 dilution.