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Home Antibody All anti-IKBß antibodies

Anti-IKBß Antibody

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319409 Rabbit polyclonal anti-IKB beta antibody 100ul $325 3-7 Days
LC419285 NFKBIB HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for IKBß (NM_002503)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenIkBb peptide corresponding to a region near the C-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsELISA: 1:5,000 - 1:25,000, WB: 1:500 - 1:3,000
BufferNone
Note NFkB was originally identified as a factor that binds to the immunoglobulin kappa light chain enhancer in B cells.  It was subsequently found in non-B cells in an inactive cytoplasmic form consisting of NFkB bound to IkB. NFkB was originally identified as a heterodimeric DNA binding protein complex consisting of p65 (RelA) and p50 (NFKB1) subunits. Other identified subunits include p52 (NFKB2), c-Rel, and RelB. The p65, cRel, and RelB subunits are responsible for transactivation. The p50 and p52 subunits possess DNA binding activity but limited ability to transactivate. p52 has been reported to form transcriptionally active heterodimers with the NFkB subunit p65, similar to p50/p65 heterodimers. The heterodimers of p52/p65 and p50/p65 are regulated by physical inactivation in the cytoplasm by IkB-a. IkB-a binds to the p65 subunit, preventing nuclear localization and DNA binding. Low levels of p52 and p50 homodimers can also exist in cells.

Reference Data

Target NameHomo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta (NFKBIB), transcript variant 1
Alternative NameIKBB; TRIP9
Database LinkNP_002494
Entrez Gene 4793 Human
Entrez Gene 18036 Mouse
Entrez Gene 81525 Rat
Function
Related PathwayStem cell - PluripotencyTranscription Factors Chemokine signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathwayT cell receptor signaling pathwayB cell receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

 

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