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Home Antibody All anti-IFNG antibodies

Anti-IFNG Antibody EP1109Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300744
  • Rabbit Monoclonal Antibody against IFNG (Clone EP1109Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400207) , 20ug
100ul 325 In Stock
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WB(1)
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Also for IFNG (NM_000619)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues human IFN- was used as an immunogen.
Clone NameEP1109Y IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:2000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens interferon, gamma (IFNG)
Alternative NameIFG; IFI
Database LinkNP_000610
FunctionInterferons (IFNs) plays a crucial role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. In particular, Interferon gamma (IFN-?), a sole member of Type II IFN family, is involved in the lymphocyte activation and the regulation of lymphocyte subsets (proliferation, differentiation) (1). IFN-? is expressed in activated CD4 Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. IFN-? expression is induced by IL-2, TNF-a and IL-12 and suppressed by IL-4, IL-10, and TGF-ß (2). IFN-? binds to IFN-? receptor (IFNGR) which stimulates various immuno-responses, such as macrophages activation and enhancement of the type I IFNs anti-viral and anti-tumor activities. In immunocompetent host cells, IFN-? protects against tumor development and directs immunogenic phenotype (3). IFN-? has been implicated various human diseases, such as multiple sclerosis and insulin-dependent diabetes mellitus (4).
Related Pathway
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Interferon gamma antibody [EP1109Y]; Anti-Interferon gamma antibody [EP1109Y] at 1/2000 dilution + recombinant protein at 0.01 µg.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 19 kDa.Observed band size : 17 kDa .

 

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