Home Antibody All anti-IFNAR1 antibodies
Anti-IFNAR1 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for IFNAR1 (NM_000629)
|DNA immunization. This antibody is specific for the Middle Region of the target protein.|
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens interferon (alpha, beta and omega) receptor 1 (IFNAR1)|
|AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC|
Entrez Gene 3454 Human
|Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- ? R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).|
|TransmembraneDruggable Genome Cytokine-cytokine receptor interactionToll-like receptor signaling pathwayJak-STAT signaling pathwayNatural killer cell mediated cytotoxicity|
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