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Home Antibody All anti-IFNAR1 antibodies
UltraMAB

Anti-IFNAR1 GAT Antibody Polyclonal

Generated by Genomic Immunization

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA590042
  • Rabbit Polyclonal IFNAR1 Antibody
100ug 325 In Stock
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ELISA(1)
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Also for IFNAR1 (NM_000629)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenDNA immunization. This antibody is specific for the Middle Region of the target protein.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1.04088
Guaranteed Application *ELISA Suggested DilutionsELISA: 1:100-1:2000
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

Target NameHomo sapiens interferon (alpha, beta and omega) receptor 1 (IFNAR1)
Alternative NameAVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC
Database LinkNP_000620
Entrez Gene 3454 Human
FunctionInterferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- ? R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interactionToll-like receptor signaling pathwayJak-STAT signaling pathwayNatural killer cell mediated cytotoxicity

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ELISA Image
ELISA: IFNAR1 Antibody

 

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