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Home Antibody All anti-IDH1 antibodies

Anti-IDH1 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319663
  • Rabbit Polyclonal IDH1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401782) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for IDH1 (NM_005896)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenIDH1 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of human IDH1.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsELISA, WB: 1 - 2 ug/ml
BufferIDH1 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification IDH1 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens isocitrate dehydrogenase 1 (NADP+), soluble (IDH1), transcript variant 1
Alternative NameHEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; PICD
Database LinkNP_005887
Entrez Gene 3417 Human
Entrez Gene 15926 Mouse
Entrez Gene 24479 Rat
FunctionIDH1 Antibody: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Two NADP(+)-dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. The presence of IDH1 in peroxisomes suggests it may play a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic IDH1 serves a significant role in cytoplasmic NADPH production. Defects in IDH1 are involved in the development of glioma.
Related Pathway Citrate cycle (TCA cycle)Glutathione metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of IDH1 in HepG2 cell lysate with IDH1 antibody at (A) 1 and (B) 2 ug/mL.

 

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