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Anti-IDE Antibody EPR6099
Also for IDE (NM_001165946)
|A synthetic peptide corresponding to residues in human IDE was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:50000; ICC: 1:50 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens insulin-degrading enzyme (IDE), transcript variant 2|
Entrez Gene 3416 Human
Entrez Gene 15925 Mouse
Entrez Gene 25700 Rat
|IDE is a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in IDE's function are associated with Alzheimer's disease and type 2 diabetes mellitus, but mutations in IDE have not been shown to be causative for these diseases. It localizes primarily in the cytoplasm, but in some cell types it localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion (1).|
|ProteaseDruggable Genome Alzheimer's disease|
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Western blot - Insulin degrading enzyme / IDE antibody [EPR6099]; All lanes : Anti-Insulin degrading enzyme / IDE antibody [EPR6099] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : A375 cell lysate.Lane 4 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 118 kDa.