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Home Antibody All anti-Hspa5 antibodies

Anti-Hspa5 Antibody

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SKU Description Amount Price Availability*  
TA326546
  • Rabbit Polyclonal Anti-GRP78 Antibody
100µg 325 3-7 Days
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OriGene Data

ImmunogenHis-tagged rat GRP78
Clone Name IsotypeN/A
Species ReactivityHuman (weak), Mouse, Rat Concentration1mg/mL
Guaranteed Application * Suggested DilutionsWB: 1:1000
BufferPBS pH7.4, 50% glyercol and 0.09% sodium azide
Purification Affinity Purified
Note Detects a 78kDa band

Reference Data

Target NameRattus norvegicus heat shock protein 5 (Hspa5)
Alternative NameBIP; GRP78
Database LinkNP_037215
FunctionGRP78 is a ubiquitously expressed, 78-kDa glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5 nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed .GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis . Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival .In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve aneuroprotective function in neurons exposed to glutamate and oxidative stress , and its protein levels are reduced in the brains of Alzheimers patients . Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to antitumor drugs .
Related Pathway

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