Home Antibody All anti-HspB8 antibodies
Anti-HspB8 Antibody N/A
Also for HspB8 (NM_206826)
|Human, Mouse, Rat. Not yet tested on other species.
|Detects ~22kDa. Does not cross-react with Hsp27 or alpha-crystallin.
|Homo sapiens guanine nucleotide binding protein-like 3 (nucleolar) (GNL3), transcript variant 3|
|C77032; E2IG3; NNP47; NS|
|Hsp22 (HSPB8) is a 196-amino acid protein that is a member of the small heat shock protein super-family and the human protein is most closely related to Hsp27. Similar to most other sHSPs, Hsp22 is predominately transcribed in skeletal muscle and heart, as well as the placenta . Hsp22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. In a two hybrid screen, HspB8 interacted preferentially with a triple aspartate form of Hsp27 which mimics Hsp27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type Hsp27 . HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs . The chaperone-like activity is of great importance to the function of Hsp22 in various processes including proliferation, apoptosis and macroautophagy . Mutations in the HSPB8 gene are associated with the inherited peripheral neurpathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L) .|
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Western blot analysis of Hsp22 in rat skeletal muscle lysates using 20ug of the antibody
IHC analysis of Hsp22 using the antibody