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Home Antibody All anti-HspB8 antibodies

Anti-HspB8 Antibody 3C12-H11

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326394
  • Mouse monoclonal Hsp22 Antibody
100µg 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenHis-tagged human recombinant hsp22
Clone Name3C12-H11 IsotypeIgG1 Kappa
Species ReactivityHuman, Mouse, Rat Concentration1mg/mL
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:2000
BufferPBS pH7.4, 50% glycerol, 0.09% sodium azide
Purification Protein G Purified
Note Detects endogenous and exogenous hsp22 in monomeric, dimeric and tetrameric forms in WB. Does not cross react with alpha crystallin.

Reference Data

Target NameHomo sapiens guanine nucleotide binding protein-like 3 (nucleolar) (GNL3), transcript variant 3
Alternative NameC77032; E2IG3; NNP47; NS
Database LinkNP_996562
Entrez Gene 26353 Human
Entrez Gene 80888 Mouse
Entrez Gene 113906 Rat
FunctionHsp22 (HSPB8) is a 196-amino acid protein that is a member of the small heat shock protein super-family and the human protein is most closely related to Hsp27. Similar to most other sHSPs, Hsp22 is predominately transcribed in skeletal muscle and heart, as well as the placenta . Hsp22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. In a two hybrid screen, HspB8 interacted preferentially with a triple aspartate form of Hsp27 which mimics Hsp27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type Hsp27 . HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs . The chaperone-like activity is of great importance to the function of Hsp22 in various processes including proliferation, apoptosis and macroautophagy . Mutations in the HSPB8 gene are associated with the inherited peripheral neurpathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L) .
Related PathwayES Cell Differentiation/IPSStem cell - Pluripotency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Hsp22 in rat tissue mix using a 1:1000 dilution of the antibody
IHC Image
IHC analysis of Hsp22, tested on mouse backskin sections. Courtesy of Dr. Turksen, Ottawa Hospital Research Institute.

 

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