Home Antibody All anti-Hdac7 antibodies
Also for Hdac7 (NM_001098416)
|Synthetic peptide surrounding amino acid 921 of murine HDAC7|
|Human, mouse, rat
||WB: 0.5-4 ug/ml, IHC: 20-40ug/ml, IP: 20-40ug/ml
|100 µg (0.2 mg/ml) affinity purified rabbit anti-HDAC7 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Homo sapiens histone deacetylase 7 (HDAC7), transcript variant 4|
Entrez Gene 51564 Human
Entrez Gene 56233 Mouse
Entrez Gene 84582 Rat
|Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription. |
|Transcription FactorsDruggable Genome |
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Western blot analysis of HDAC7 expression in mouse small intestine tissue lysate.