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Home Antibody All anti-Hcn4 antibodies

Anti-Hcn4 Antibody S114-10

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326545
  • Mouse Monoclonal Anti-HCN4 Antibody
100µg 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenFusion protein amino acids 1-019-1198 (c-terminus) of rat HCN4,
Clone NameS114-10 IsotypeIgG1
Species ReactivityHuman, Mouse, Rat Concentration1mg/mL
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1-10ug/ml, IHC: 0.1-1.0ug/ml, IF: 1.0-10ug/ml
BufferPBS pH7.4, 50% glycerol
Purification Protein G Purified
Note Detects ~130kDa. No cross-reactivity against other HCNs

Reference Data

Target NameRattus norvegicus hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (Hcn4)
Alternative Name
Database LinkNP_067690
Entrez Gene 10021 Human
Entrez Gene 330953 Mouse
Entrez Gene 59266 Rat
FunctionIon channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient . They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels .Specifically, hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both the heart and brain .
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of HCN4 in T-HEK cells using a 1:1000 dilution of the antibody
IHC Image
IHC analysis of HCN4 in frozen sections of mouse brain extracts using the antibody

 

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