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Anti-HUWE1 Antibody


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TA306429 Rabbit Polyclonal ARF-BP1 Antibody 100ug $325 In Stock
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OriGene Data

ImmunogenARF-BP1 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human ARF-BP1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1)
Alternative NameARF-BP1; HECTH9; HSPC272; Ib772; LASU1; MULE; URE-B1; UREB1
Database LinkNP_113584
Entrez Gene 10075 Human
Entrez Gene 59026 Mouse
Entrez Gene 501546 Rat
FunctionThe ARF tumor suppressor is a critical regulator of p53 stability. In addition to p53, ARF1 binds to other proteins such as MDM2 and ARF-BP1, a large protein containing HECT, UBA and WWE motifs. ARF-BP1 directly binds and ubiquitinates p53; this activity is inhibited by ARF, indicating that ARF-BP1 is a critical mediator of the p53-dependent and p53-independent tumor suppressor functions of ARF. ARF-BP1 can also catalyze the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involved in DNA damage-induced apoptosis. Elimination of ARF-BP1 expression by RNA interference stabilized Mcl-1 protein, resulting in an attenuation of apoptosis induced by DNA-damage agents.
Related PathwayDruggable Genome Ubiquitin mediated proteolysis

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Western blot analysis of ARF-BP1 in Daudi cell lysate with ARF-BP1 antibody at 1 ug/mL.
Immunocytochemistry of ARF-BP1 in Daudi cells with ARF-BP1 antibody at 5 ug/mL.


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