Home Antibody All anti-HTR2C antibodies
Also for HTR2C (NM_000868)
| Peptide with sequence C-QVENLELPVN, from the internal region of the protein sequence according to NP_000859.1.|
|Test: Human. Expected from seq similarity: Human, Mouse, Rat, Dog, Cow
||ELISA: 1:64,000. WB: 1-3µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled (HTR2C), transcript variant 2|
|5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C|
Entrez Gene 3358 Human
Entrez Gene 15560 Mouse
Entrez Gene 25187 Rat
Entrez Gene 450240 Dog
|Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq]. |
|GPCRTransmembraneDruggable Genome Calcium signaling pathwayNeuroactive ligand-receptor interactionGap junction|
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TA303035 (1µg/ml) staining of EBV immortalised Lymphoblastoid lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.