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Anti-HSPD1 Antibody EP1006Y
Also for HSPD1 (NM_002156)
|A synthetic peptide corresponding to residues in the internal region of human Hsp60 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:5000; IHC: 1: 100-250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens heat shock 60kDa protein 1 (chaperonin) (HSPD1), transcript variant 1|
|CPN60; GROEL; HLD4; HSP-60; HSP60; HSP65; HuCHA60; SPG13|
Entrez Gene 3329 Human
Entrez Gene 15510 Mouse
Entrez Gene 63868 Rat
|The 60-kDa Heat Shock Protein (Hsp60) is a highly conserved member of the molecular chaperone network commonly imported into the mitochondria to assist in the folding and assembly of mitochondrial proteins (1). Under environmental stress conditions, synthesis of Hsp60 is up-regulated then involved in gene expression regulation, DNA replication, signal transduction, differentiation, apoptosis, cellular senescence or immortalization (2). Hsp60 is also believed to protect mitochondrial ATPase activity under conditions of increasing temperature (3). Hsp60, along with Hsp70, has also been shown to play a role in a danger signalling cascade in response to bacterial infection (4). |
|Stem cell - PluripotencyDruggable Genome RNA degradationType I diabetes mellitus|
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Western blot - Hsp60 antibody [EP1006Y]; Anti-Hsp60 antibody [EP1006Y] at 1/5000 dilution + T47D cell lysate at 10 ug.Secondary.Goat anti-Rabbit HRP labelled, at 1/2000 dilution.Predicted band size : 60 kDa.Observed band size : 60 kDa.
Immunohistochemistry (Paraffin-embedded sections) - Hsp60 antibody [EP1006Y]; Ab45134 at 1/100 staining human Hsp60 in human breast carcinoma by immunohistochemistry using paraffin embedded tissue.