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Home Antibody All anti-HSD17B1 antibodies

Anti-HSD17B1 Antibody EP1681Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307711
  • Rabbit monoclonal antibody against HSD17B1 (C-term) (clone EP2358Y )
100ul 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human HSD17B1 was used as an immunogen.
Clone NameEP1681Y IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:2000; IHC-P: 1:100 - 1:250; FC: 1:40; ICC/IF: 1:50
BufferDoes not react with Mouse, Rat. Is unsuitable for IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens hydroxysteroid (17-beta) dehydrogenase 1 (HSD17B1)
Alternative NameEDH17B2; EDHB17; HSD17; SDR28C1
Database LinkNP_000404
FunctionThe principal human estrogen, 17 beta-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth (1). It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step (2). Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies (3). Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia (4)
Related Pathway

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WB Image
Western blot - Anti-HSD17B1 antibody [EP1681Y]; Anti-HSD17B1 antibody [EP1681Y] at 1/500 dilution + Human placenta lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 35 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSD17B1 antibody [EP1681Y]; Immunohistochemical analysis of paraffin-embedded Human placenta tissue labelling HSD17B1 with TA307711 at 1/100 dilution.

 

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