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Home Antibody All anti-HRK antibodies

Anti-HRK Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306305
  • Rabbit Polyclonal Hrk Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401253) , 20ug
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenHRK antibody was raised against a 15 amino acid peptide from near the center of human Hrk.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 2.5 - 5 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant 1
Alternative NameDP5; HARAKIRI
Database LinkNP_003797
FunctionApoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL. Despite its predicted molecular weight, Hrk often migrates at 12-15 kDa.
Related Pathway
Apoptosis

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WB Image
Western blot analysis of Hrk in mouse pancreas tissue lysate with Hrk antibody at (A) 2.5 and (B) 5 µg/ml.

 

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