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Anti-HNRNPM Antibody 2A6
Also for HNRNPM (NM_031203)
|M19 fusion protein containing full-length human protein.|
|human, mouse, rat, bovine, porcine, rabbit
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1: 1000-1: 10,000
|Ascitic fluid and sodium azide|
|Ascites (Protein A or G Sepharose)
|Homo sapiens heterogeneous nuclear ribonucleoprotein M (HNRNPM), transcript variant 2|
|CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4; HTGR1; NAGR1|
|Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3'-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast. |
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HEK293T cells were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY HNRNPM (RC220513) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HNRNPM.