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Home Antibody All anti-HNRNPK antibodies

Anti-HNRNPK Antibody EPR944

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307474
  • Rabbit monoclonal antibody against hnRNP K(clone EPR944)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400779) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for HNRNPK (NM_002140)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human hnRNP K was used as an immunogen
Clone NameEPR944 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:50000 - 1:200000; IHC-P: 1:100 - 1:250
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens heterogeneous nuclear ribonucleoprotein K (HNRNPK), transcript variant 1
Alternative NameCSBP; HNRPK; TUNP
Database LinkNP_002131
Entrez Gene 3190 Human
Entrez Gene 15387 Mouse
Entrez Gene 117282 Rat
FunctionThe hnRNP K family of acidic nuclear proteins has been identified using a monoclonal antibody that distinguishes between quiescent and proliferating human keratinocytes. The family, which is composed of four major proteins (hnRNP K A, B, C and D) and their modified forms, is present in similar overall levels in quiescent and proliferating normal keratinocytes; although clear differences were observed in the levels of some of the individual variants (1). hnRNP-K is an ancient RNA/DNA-binding protein that is involved in multiple processes that compose gene expression. The pleiotropic action of K protein reflects its ability to interact with different classes of factors, interactions that are regulated by extracellular signals (2). hnRNP-K has several different cellular roles including transcription, mRNA shuttling, RNA editing and translation. Several reports implicate hnRNP K having a role in tumorigenesis; for instance, hnRNP K increases transcription of the oncogene c-myc, and hnRNP K expression is regulated by the p53/MDM 2 pathway (3).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-hnRNP K antibody [EPR944]; All lanes : Anti-hnRNP K antibody [EPR944] at 1/50000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : A549 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 50 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hnRNP K antibody [EPR944]; Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue labelling hnRNP K with TA307474 at 1/100 dilution.

 

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