OriGene Technologies, Inc.
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-HNRNPK antibodies

Anti-HNRNPK Antibody EP943Y

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300758
  • Rabbit Monoclonal Antibody against HNRNPK (Clone EP943Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400779) , 20ug
100ul 325 3-7 Days
Add to Shopping Cart
WB(1)
IHC(1)
IF(1)
spacer
Also for HNRNPK (NM_002140)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human hnRNP was used as an immunogen. This antibody detects both phosphorylated and unphosphorylated hnRNP K.
Clone NameEP943Y IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:100000; IP: 1:50; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens heterogeneous nuclear ribonucleoprotein K (HNRNPK), transcript variant 1
Alternative NameCSBP; HNRPK; TUNP
Database LinkNP_002131
FunctionThe hnRNP-K family of acidic nuclear proteins has been identified using a monoclonal antibody that distinguishes between quiescent and proliferating human keratinocytes. The family, which is composed of four major proteins (hnRNPs-K A, B, C and D) and their modified forms, is present in similar overall levels in quiescent and proliferating normal keratinocytes although clear differences were observed in the levels of some of the individual variants (1). hnRNP-K is an ancient RNA/DNA-binding protein that is involved in multiple processes that compose gene expression. The pleiotropic action of K protein reflects its ability to interact with different classes of factors, interactions that are regulated by extracellular signals (2). hnRNP-K has several different cellular roles including transcription, mRNA shuttling, RNA editing and translation. Several reports implicate hnRNP K having a role in tumorigenesis, for instance hnRNP K increases transcription of the oncogene c-myc and hnRNP K expression is regulated by the p53/MDM 2 pathway (3).
Related Pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - hnRNP K antibody [EP943Y]; Anti-hnRNP K antibody [EP943Y] at 1/100000 dilution + Jurkat cell lysate at 10 µg.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 kDa.Observed band size : ~60 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - hnRNP K antibody [EP943Y]; Immunohistochemical staining of paraffin-embedded human breast carcinoma tissue using TA300758 at a dilution of 1/100-1/250.
IF Image
Immunocytochemistry/ Immunofluorescence - hnRNP K antibody [EP943Y]; Fluorescent immunostaining of HeLa cells using TA300758 at a dilution of 1/100-1/250.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title