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Anti-HMGB2 Antibody EPR6301

WB(1)

IHC(1)

Gene Name Homo sapiens high mobility group box 2 (HMGB2), transcript variant 2 Synonyms: HMG2 Immunogen A synthetic peptide corresponding to residues on the N-terminus in human HMGB2 was used as an immunogen. Buffer Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt. Clone Name EPR6301 Isotype Species Reactivity Human, Mouse, Rat Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB, IHC Suggested Dilutions WB: 1:10,000 - 50,000; FC: 1:10 - 100; Background HMGB2 is a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. HMGB2 was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination (1). Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of high-mobility group box 2 (HMGB2), transcript variant 2 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • HMGB2 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • HMGB2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Hmgb2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • HMGB2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Hmgb2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens high mobility group box 2 (HMGB2), transcript variant 2 as transfection-ready DNA • Lenti ORF clone of Human high mobility group box 2 (HMGB2), transcript variant 2 , Myc-DDK-tagged • Lenti ORF clone of Human high mobility group box 2 (HMGB2), transcript variant 2, mGFP tagged • GFP-tagged ORF clone of Homo sapiens high mobility group box 2 (HMGB2), transcript variant 2 as transfection-ready DNA Related cDNA Clones • Homo sapiens high mobility group box 2 (HMGB2), transcript variant 2 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)