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Home Antibody All anti-HLA-G antibodies

Anti-HLA-G Antibody 87G

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA320347
  • Mouse Anti-Human HLA-G Purified (100 ug)
100ug 120 3-7 Days
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FC(1)
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Also for HLA-G (NM_002127)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

Immunogen
Clone Name87G Isotype
Species ReactivityHuman Concentration0.5-1mg/ml (lot dependent)
Guaranteed Application *FC Suggested DilutionsFlow, IHC
BufferAqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Purification Affinity purified

Reference Data

Target NameHomo sapiens major histocompatibility complex, class I, G (HLA-G)
Alternative NameMHC-G
Database LinkNP_002118
Entrez Gene 3135 Human
FunctionThe monoclonal antibody 87G recognizes human HLA-G, a member of the Human Leukocyte Antigen family but as part of the nonclassical MHC type involved in inhibiting immune reponses. HLA-G has seven reported isoforms. The antibody 87G recognizes both HLA-G1 and the solube HLA-G5. Expression of HLA-G is found primarily in fetal trophoblast cells as they invade the maternal decidua thereby protecting the fetus from the maternal immune system. Like the highly mitotic trophoblast, abundant HLA-G protein expression has been identified in some tumors, including melanoma, breast carcinoma and renal carcinoma as well as CLL, AML and B-CLL. Some expression has also been found in pancreatic islets, erythroid and endothelial progenitors and the adult thymic medulla.HLA-G+ CD4 or CD8 cells have been identified in normal human peripheral blood and are thought to act as regulatory cells in that they are hypoproliferative with a unique cytokine profile differing from Tregs. The receptors for HLA-G are CD85j/ILT2, CD85d/ILT4, and CD158. Recent studies have shown a role for HLA-G in tolerance and maintenance of transplanted organs.
Related PathwayTransmembrane EndocytosisCell adhesion molecules (CAMs)Antigen processing and presentationNatural killer cell mediated cytotoxicityType I diabetes mellitusAutoimmune thyroid diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

FC Image
Staining of stimulated U937 cells with 0.25 ug of Mouse IgG2a K Isotype Control Purified (blue) or 0.25 ug of Anti-Human HLA-G Purified (purple) followed by F(ab')2 Anti-Mouse IgG PE . Total viable cells were used for analysis.

 

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